In the 2010/11 UEFA Champions League Group Stage, Panathinaikos was drawn in Group D with FC Barcelona (ESP), FC Kobenhavn (DEN) and FC Rubin Kazan (RUS).
| Matchday 1 (14.9.2010) | FC Barcelona – Panathinaikos FC |
| FC Kobenhavn – FC Rubin Kazan | |
| Matchday 2 (29.9.2010) | FC Rubin Kazan – FC Barcelona |
| Panathinaikos FC – FC Kobenhavn | |
| Matchday 3 (20.10.2010) | Panathinaikos FC – FC Rubin Kazan |
| FC Barcelona – FC Kobenhavn | |
| Matchday 4 (2.11.2010) | FC Rubin Kazan – Panathinaikos FC |
| FC Kobenhavn – FC Barcelona | |
| Matchday 5 (24.11.2010) | Panathinaikos FC – FC Barcelona |
| FC Rubin Kazan – FC Kobenhavn | |
| Matchday 6 (7.12.2010) | FC Barcelona – FC Rubin Kazan |
| FC Kobenhavn – Panathinaikos FC |