In the 2010/11 UEFA Champions League Group Stage, Panathinaikos was drawn in Group D with  FC Barcelona (ESP), FC Kobenhavn (DEN) and  FC Rubin Kazan (RUS).

Matchday 1 (14.9.2010)FC Barcelona – Panathinaikos FC
FC Kobenhavn – FC Rubin Kazan
Matchday 2 (29.9.2010)FC Rubin Kazan – FC Barcelona
Panathinaikos FC – FC Kobenhavn
  Matchday 3 (20.10.2010)Panathinaikos FC – FC Rubin Kazan
FC Barcelona – FC Kobenhavn
Matchday 4 (2.11.2010)FC Rubin Kazan – Panathinaikos FC
FC Kobenhavn – FC Barcelona
 Matchday 5 (24.11.2010)Panathinaikos FC – FC Barcelona
FC Rubin Kazan – FC Kobenhavn
Matchday 6 (7.12.2010)FC Barcelona – FC Rubin Kazan
FC Kobenhavn – Panathinaikos FC